Romidepsin

{
  "id": "MLC-T-ONC-007490",
  "term": "Romidepsin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat adults with cutaneous T-cell lymphoma that has already been treated with at least one other type of systemic therapy. It is also being studied in the treatment of other types of cancer. Romidepsin blocks certain enzymes needed for cell division and may kill cancer cells. It is a type of depsipeptide and a type of histone deacetylase inhibitor. Also called FR901228 and Istodax.",
    "A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation, romidepsin binds to and inhibits histone deacetylase (HDAC), resulting in alterations in gene expression and the induction of cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia-induced angiogenesis and depletes several heat shock protein 90 (Hsp90)-dependent oncoproteins."
  ],
  "synonyms": [
    "FR901228",
    "Istodax",
    "depsipeptide"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/romidepsin/"
}