romiplostim

{
  "id": "MLC-T-ONC-007491",
  "term": "romiplostim",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat thrombocytopenia (a low blood platelet count) in adults and in certain children with immune thrombocytopenic purpura that did not get better with other treatment. It is also being studied in the treatment of other conditions and types of cancer. Romiplostim binds to the thrombopoietin receptor, which causes the bone marrow to make more platelets. It is a type of thrombopoietin receptor agonist. Also called AMG 531 and Nplate.",
    "A recombinant protein with megakaryopoiesis stimulating activity. Romiplostim mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TpoR stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets."
  ],
  "synonyms": [
    "AMG 531",
    "Nplate",
    "Amgen megakaryopoiesis protein 2"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/romiplostim/"
}