samarium Sm 153-DOTMP

{
  "id": "MLC-T-ONC-016633",
  "term": "samarium Sm 153-DOTMP",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of the phosphonic acid chelator DOTMP (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic acid) conjugated to the beta- and gamma-emitting radioisotope samarium Sm 153, with potential antineoplastic activity. Upon administration of samarium Sm 153-DOTMP, the DOTMP moiety targets and binds to growing bone, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to bone tumor and metastases, which may help destroy bone metastases and mitigate pain from bone metastases.",
  "synonyms": [
    "153Sm-DOTMP",
    "Sm-153-DOTMP",
    "153 Sm-DOTMP"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/samarium-sm-153-dotmp/"
}