saquinavir mesylate

Term · Oncology and biomedicine · MLC-T-ONC-007548

A drug that belongs to the family of drugs called protease inhibitors. It interferes with the ability of a virus to make copies of itself.
The mesylate salt form of saquinavir, a synthetic peptidomimetic substrate with antiviral property. Saquinavir selectively binds to and inhibits human immunodeficiency virus type 1 (HIV-1) protease, an aspartic protease that cleaves viral gag and gag-pol polyprotein (precursors for viral proteases, reverse transcriptase, and integrase). Inhibition of HIV-1 protease prevents functional viral proteins to be cleaved from the viral polyprotein precursor and results in the release of immature, noninfectious virions.

Table 1. Record
Identifier	MLC-T-ONC-007548
Field	Oncology and biomedicine
References	NCI Dictionary of Cancer Terms; National Cancer Institute Thesaurus (CC BY 4.0)

Record as JSON

{
  "id": "MLC-T-ONC-007548",
  "term": "saquinavir mesylate",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug that belongs to the family of drugs called protease inhibitors. It interferes with the ability of a virus to make copies of itself.",
    "The mesylate salt form of saquinavir, a synthetic peptidomimetic substrate with antiviral property. Saquinavir selectively binds to and inhibits human immunodeficiency virus type 1 (HIV-1) protease, an aspartic protease that cleaves viral gag and gag-pol polyprotein (precursors for viral proteases, reverse transcriptase, and integrase). Inhibition of HIV-1 protease prevents functional viral proteins to be cleaved from the viral polyprotein precursor and results in the release of immature, noninfectious virions."
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/saquinavir-mesylate/"
}

Record 14,681 of 17,721 in Oncology and biomedicine terminology (MLC-0111). Request the full dataset.