Seneca Valley virus-001

{
  "id": "MLC-T-ONC-007659",
  "term": "Seneca Valley virus-001",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A virus being studied in the treatment of neuroendocrine tumors and other types of cancer. Neuroendocrine tumors form from cells that release hormones in response to a signal from the nervous system. The virus infects and breaks down these tumor cells but not normal cells. It is a type of oncolytic virus. Also called NTX-010 and SVV-001.",
    "A native, replication-competent oncolytic picornavirus with potential antineoplastic activity. Administered systemically, Seneca Valley virus-001 (SVV-001) specifically targets and infects tumor cells with neuroendocrine characteristics. Upon infection, this agent replicates intracellularly, resulting in tumor cell lysis and reduced tumor cell proliferation. The selective tropism of virus replication may involve receptor-mediated internalization."
  ],
  "synonyms": [
    "NTX-010",
    "SVV-001"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/seneca-valley-virus-001/"
}