sirolimus protein-bound nanoparticles

{
  "id": "MLC-T-ONC-016753",
  "term": "sirolimus protein-bound nanoparticles",
  "field": "Oncology and biomedicine",
  "definition": "The macrolide antibiotic rapamycin bound to nanoparticle albumin with immunosuppressant (see sirolimus) and potential antiangiogenic and antineoplastic activities. Rapamycin binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate a complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. In turn, inhibition of mTOR may result in the inhibition of the phosphatidylinositol 3 (PI-3) kinase/Akt pathway and vascular endothelial cell growth factor (VEGF) secretion, which may result in decreased tumor cell proliferation and tumor angiogenesis. The binding of water-insoluble rapamycin to nanoparticle albumin permits the albumin-mediated endocytosis of rapamycin by tumor cells and endothelial cells.",
  "synonyms": [
    "albumin-bound sirolimus",
    "nab-sirolimus",
    "nab-rapamycin",
    "nanoparticle albumin-bound rapamycin",
    "sirolimus albumin-bound nanoparticles",
    "nanoparticle albumin-bound sirolimus",
    "sirolimus albumin-bound particles"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/sirolimus-protein-bound-nanoparticles/"
}