Nanoparticle albumin-bound docetaxel

{
  "id": "MLC-T-ONC-015420",
  "term": "Nanoparticle albumin-bound docetaxel",
  "field": "Oncology and biomedicine",
  "definition": "A nanoparticle albumin-bound formulation of the taxane docetaxel with antineoplastic activity. Docetaxel is a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. This nanoparticle albumin-bound formulation solubilizes docetaxel without the use of the nonionic solubilizer Cremophor ELP, permitting the administration of larger doses of docetaxel while avoiding Cremophor ELP-associated toxicity.",
  "abbreviation": "DTX-HSA",
  "synonyms": [
    "docetaxel albumin-bound",
    "nab-docetaxel"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nanoparticle-albumin-bound-docetaxel/"
}