protein stabilized liposomal docetaxel nanoparticles

{
  "id": "MLC-T-ONC-016263",
  "term": "protein stabilized liposomal docetaxel nanoparticles",
  "field": "Oncology and biomedicine",
  "definition": "A formulation containing protein-stabilized liposome nanoparticles encapsulating the poorly water-soluble, second-generation taxane analog docetaxel with antineoplastic activity. Docetaxel binds to and stabilizes the beta-tubulin subunit, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Compared to the use of toxic carriers to increase solubilization of docetaxel, protein-stabilized liposomal docetaxel improves drug solubility while avoiding carrier-associated toxicity.",
  "synonyms": [
    "protein-stabilized nanoparticle-bound docetaxel ATI-1123"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/protein-stabilized-liposomal-docetaxel-nanoparticles/"
}