docetaxel depot formulation NZ-DTX

{
  "id": "MLC-T-ONC-013115",
  "term": "docetaxel depot formulation NZ-DTX",
  "field": "Oncology and biomedicine",
  "definition": "A depot formulation containing the taxane docetaxel, a semisynthetic analogue of paclitaxel, with antineoplastic activity. Upon intratumoral administration, docetaxel depot formulation NZ-DTX forms a solid depot allowing the controlled release of docetaxel. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response.",
  "synonyms": [
    "NZ-DTX depot",
    "NanoZolid-docetaxel depot",
    "localized extended-release docetaxel"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/docetaxel-depot-formulation-nz-dtx/"
}