SORT1-targeted docetaxel TH1902

{
  "id": "MLC-T-ONC-016824",
  "term": "SORT1-targeted docetaxel TH1902",
  "field": "Oncology and biomedicine",
  "definition": "A peptide-drug conjugate composed of the second-generation taxane docetaxel and the sortilin (SORT1)-targeting peptide TH19P01, with potential antineoplastic activity. Upon administration of SORT1-targeted docetaxel TH1902, the TH19P01 moiety targets and binds to SORT1 expressed on tumor cells. Upon internalization, docetaxel binds to and stabilizes the beta-tubulin subunit, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell death. SORT1 is overexpressed in a variety of cancers and plays an important role in protein internalization, sorting and trafficking.",
  "synonyms": [
    "docetaxel-TH19P01 conjugate TH1902",
    "sortilin-targeted docetaxel TH1902"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/sort1-targeted-docetaxel-th1902/"
}