Docetaxel/ritonavir

{
  "id": "MLC-T-ONC-013124",
  "term": "Docetaxel/ritonavir",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable combination agent containing docetaxel, a second generation taxane, and ritonavir, a cytochrome P450 (CYP) 3A4 inhibitor, with potential enhanced antineoplastic activity. Docetaxel binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell death. Docetaxel is metabolized by CYP3A4 enzymes which is inhibited by the presence of ritonavir. This increases the plasma concentration of docetaxel and may increase docetaxel’s efficacy.",
  "synonyms": [
    "oral docetaxel/ritonavir",
    "ModraDoc006/r"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/docetaxel-ritonavir/"
}