Sodium phenylbutyrate

{
  "id": "MLC-T-ONC-016806",
  "term": "Sodium phenylbutyrate",
  "field": "Oncology and biomedicine",
  "definition": "The sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.",
  "synonyms": [
    "sodium 4-phenylbutyrate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/sodium-phenylbutyrate/"
}