STAT3 inhibitor DSP-0337

{
  "id": "MLC-T-ONC-016869",
  "term": "STAT3 inhibitor DSP-0337",
  "field": "Oncology and biomedicine",
  "definition": "An orally administered prodrug of napabucasin, a small molecule cancer stemness inhibitor with potential antineoplastic activity. Upon administration, DSP-0337 is converted to its active form, napabucasin. Napabucasin targets and inhibits signal transducer and activator of transcription 3 (STAT3), thereby preventing STAT-3-mediated signaling. The STAT3 pathway is overly active in many cancer types and is implicated in cancer stem cell-mediated growth, recurrence and resistance to conventional chemotherapies.",
  "synonyms": [
    "napabucasin prodrug DSP-0337",
    "cancer stemness inhibitor DSP-0337"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/stat3-inhibitor-dsp-0337/"
}