tacrolimus

{
  "id": "MLC-T-ONC-008488",
  "term": "tacrolimus",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants.",
    "A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent."
  ],
  "synonyms": [
    "fujimycin"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tacrolimus/"
}