Technetium Tc 99m methylene diphosphonate

{
  "id": "MLC-T-ONC-017021",
  "term": "Technetium Tc 99m methylene diphosphonate",
  "field": "Oncology and biomedicine",
  "definition": "A radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with radioisotopic activity and hydroxyapatite affinity. Upon intravenous administration, skeletal uptake of technetium Tc 99m methylene diphosphonate occurs as a function of skeletal blood flow and osteogenic activity. The MDP moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization; labeling of MDP with Tc 99m allows scinitgraphic imaging of areas of abnormal osteogenesis associated with malignant bone lesions.",
  "abbreviation": "99mTc-MDP",
  "synonyms": [
    "technetium Tc 99m medronate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/technetium-tc-99m-methylene-diphosphonate/"
}