Thrombomodulin alfa

{
  "id": "MLC-T-ONC-017151",
  "term": "Thrombomodulin alfa",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant, soluble form of the human protein thrombomodulin, with potential anticoagulant activity. Upon administration, thrombomodulin binds to thrombin, which stimulates the activation of protein C. Activated protein C (APC) degrades factor Va and Factor VIIa in the presence of the cofactor protein S, inhibits thrombin formation, and prevents both thrombin-mediated coagulation and further clot formation.",
  "abbreviation": "Tma",
  "synonyms": [
    "recomodulin",
    "thrombomodulin (human 498-amino acid fragment)",
    "1-498-thrombomodulin (human clone TMP26/TMJ1 protein moiety reduced)"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/thrombomodulin-alfa/"
}