topoisomerase I/II inhibitor NEV-801

{
  "id": "MLC-T-ONC-017267",
  "term": "topoisomerase I/II inhibitor NEV-801",
  "field": "Oncology and biomedicine",
  "definition": "A multi-targeted agent with potential antineoplastic activity. Upon administration, NEV-801 appears to selectively inhibit topoisomerase (Topo) I and II, and activates hypoxia-inducible factor 1 (HIF-1) transcription and the expression of vascular endothelial growth factor (VEGF) mRNA. NEV-801 is also able to overcome multidrug resistance (MDR) 1-mediated resistance.",
  "synonyms": [
    "TopI/II NEV-801"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/topoisomerase-i-ii-inhibitor-nev-801/"
}