tozasertib lactate

{
  "id": "MLC-T-ONC-017280",
  "term": "tozasertib lactate",
  "field": "Oncology and biomedicine",
  "definition": "The lactate salt of tozasertib, a synthetic, small-molecule Aurora kinase inhibitor with potential antitumor activity. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed. AKs, a family of serine-threonine kinases, are essential for mitotic progression, spindle formation, centrosome maturation, chromosomal segregation, and cytokinesis.",
  "synonyms": [
    "Aurora kinase inhibitor MK-0457"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tozasertib-lactate/"
}