Treosulfan

{
  "id": "MLC-T-ONC-008889",
  "term": "Treosulfan",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug given with fludarabine phosphate before a donor hematopoietic stem cell transplant in adults and children aged 1 year and older with acute myeloid leukemia or myelodysplastic syndrome. It is also being studied in the treatment of other types of cancer. Treosulfan may kill cancer cells by damaging their DNA and stopping them from dividing. It is a type of alkylating agent. Also called Grafapex.",
    "The prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppressive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhibits myeloablative and immunosuppressive activities."
  ],
  "synonyms": [
    "Grafapex",
    "dihydroxybusulfan",
    "treosulphan",
    "tresulfon"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/treosulfan/"
}