tremtelectogene empogeditemcel

{
  "id": "MLC-T-ONC-017312",
  "term": "tremtelectogene empogeditemcel",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, human leukocyte antigen (HLA) matched, cluster of differentiation 34 (CD34)-positive human hematopoietic stem and progenitor cells (HSPCs) that are ex-vivo gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to remove the cluster of differentiation 33 (CD33) antigen, that can potentially be used to improve hematopoietic recovery after hematopoietic cell transplantation (HCT) and CD33-targeting chemotherapy. Upon administration, tremtelectogene empogeditemcel increases and restores the number of HSPCs, which may prevent or decrease infection and other complications of HCT and chemotherapy-induced neutropenia (CIN). The removal of CD33 protects VOR33 from the cytotoxic effects of CD33-targeted agents administered after HCT.",
  "synonyms": [
    "allogeneic CRISPR/Cas9-edited CD33-depleted CD34-positive HSPCs VOR33",
    "allogeneic CRISPR/Cas9-edited CD33-depleted CD34-positive HSCs VOR33",
    "eHSCs VOR33",
    "allogeneic CRISPR/Cas9-edited CD33-depleted CD34-positive hematopoietic stem and progenitor cells VOR33",
    "Trem-cel"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tremtelectogene-empogeditemcel/"
}