allogeneic gene-edited CD33-knockout hematopoietic stem and progenitor cells

{
  "id": "MLC-T-ONC-009887",
  "term": "allogeneic gene-edited CD33-knockout hematopoietic stem and progenitor cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of human allogeneic hematopoietic stem and progenitor cells (HSPCs) that are ex-vivo gene-edited to remove the cluster of differentiation 33 (CD33) antigen, that can potentially be used to improve hematopoietic recovery after hematopoietic cell transplantation (HCT) and CD33-targeting therapy. Upon administration, allogeneic gene-edited CD33-knockout HSPCs increase and restore the number of HSPCs, which may prevent or decrease infection and other complications of HCT and chemotherapy-induced neutropenia (CIN). The removal of CD33 protects the agent from the cytotoxic effects of CD33-targeted agents administered after HCT.",
  "synonyms": [
    "allogeneic CD33KO-HSPC",
    "allogeneic gene-edited CD33-depleted HSCs",
    "allogeneic gene-edited CD33-knockout HSPCs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-gene-edited-cd33-knockout-hematopoietic-stem-and-progenitor-cells/"
}