Trimethoprim-sulfamethoxazole

{
  "id": "MLC-T-ONC-008909",
  "term": "Trimethoprim-sulfamethoxazole",
  "field": "Oncology and biomedicine",
  "definitions": [
    "An antibiotic drug used to treat infection and prevent pneumocystis carinii pneumonia.",
    "A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as Co-Trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthase."
  ],
  "abbreviation": "SMZ-TMP",
  "synonyms": [
    "cotrimoxazole",
    "Eslectin",
    "insozalin",
    "trimedin",
    "trimezole",
    "Bactrimel",
    "Centran",
    "Centrin",
    "Trimethoprim/Sulfamethoxazole"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/trimethoprim-sulfamethoxazole/"
}