TRK inhibitor TQB3558

{
  "id": "MLC-T-ONC-017339",
  "term": "TRK inhibitor TQB3558",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of tropomyosin receptor kinase (Trk), with potential antineoplastic activity. Upon oral administration, Trk inhibitor TQB3558 targets and binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation. This may lead to apoptosis of Trk-expressing tumor cells and the inhibition of tumor cell proliferation in Trk-expressing tumors. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival.",
  "synonyms": [
    "tropomyosin receptor kinase inhibitor TQB3558"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/trk-inhibitor-tqb3558/"
}