TRK inhibitor TQB3811

{
  "id": "MLC-T-ONC-017340",
  "term": "TRK inhibitor TQB3811",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of tropomyosin receptor kinase (TRK), with potential antineoplastic activity. Upon oral administration, TRK inhibitor TQB3811 targets and binds to TRK, thereby preventing neurotrophin-TRK interaction and TRK activation. This may lead to apoptosis of TRK-expressing tumor cells and the inhibition of tumor cell proliferation in TRK-expressing tumors. Members of TRK, a family of receptor tyrosine kinases activated by neurotrophins, are mutated in a variety of cancer cell types and play an important role in tumor cell growth and survival.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/trk-inhibitor-tqb3811/"
}