utatrectinib

{
  "id": "MLC-T-ONC-017433",
  "term": "utatrectinib",
  "field": "Oncology and biomedicine",
  "definition": "A tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. Upon administration, utatrectinib binds to TRK, thereby preventing the neurotrophin-TRK interaction and subsequent TRK activation. This may eventually result in an inhibition of tumor cell proliferation in TRK-expressing tumor cells. TRK, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth, invasion and survival.",
  "synonyms": [
    "TRK inhibitor AZD7451",
    "tropomyosin receptor kinase inhibitor AZD7451"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/utatrectinib/"
}