umbilical cord blood-derived natural killer cells

{
  "id": "MLC-T-ONC-017400",
  "term": "umbilical cord blood-derived natural killer cells",
  "field": "Oncology and biomedicine",
  "definition": "A population of allogeneic, cytokine-differentiated, highly lytic natural killer (NK) cells derived from CD34+ cells isolated from human umbilical cord blood (UCB) with potential cytotoxic activity. CD34+ hematopoietic stem cells (HSC) are isolated from human UCB mononuclear cells, differentiated into mature, highly lytic, CD3- CD56+ NK cells, by a specific combination of cytokines that includes stem cell factor (SCF), fms-related tyrosine kinase 3 ligand (Flt3-L), interleukin-15 (IL-15) and insulin-like growth factor-1 (IGF-1), and expanded ex vivo. Upon administration, the UCB-derived NK cells may lyse cancer cells.",
  "synonyms": [
    "umbilical cord blood-derived NK cells",
    "cord blood NK cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/umbilical-cord-blood-derived-natural-killer-cells/"
}