Clavulanic acid

{
  "id": "MLC-T-AGR-001343",
  "term": "Clavulanic acid",
  "field": "Agriculture and food",
  "definitions": [
    "Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase.",
    "Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects."
  ],
  "subject": "Research, Technology, Methods",
  "see_also": [
    "clavulanic acids",
    "beta-lactam antibiotics",
    "beta-lactams",
    "clavulanic acid"
  ],
  "references": [
    "Medical Subject Headings 2011",
    "NAL Agricultural Thesaurus and Glossary"
  ],
  "translations": {
    "es": "ácido clavulánico"
  },
  "url": "https://mlchart.com/terminology/agriculture/clavulanic-acid/"
}