Dose Additivity

{
  "id": "MLC-T-ENV-008439",
  "term": "Dose Additivity",
  "field": "Environment",
  "definition": "1. The Agency's assumption when evaluating the joint risk of chemicals that are toxicologically similar and act at the same target site. In other words, it is assumed that each chemical behaves as a concentration or dilution of every other chemical in the CAG or chemical mixture). The response of the combination is the response expected from the equivalent dose of an index chemical. The equivalent dose is the sum of the component doses, scaled by each chemical's toxic potency relative to the index chemical.\n\n2. In a mixture, when each chemical behaves as a concentration or dilution of every other chemical. The response of the combination of chemicals is the response expected from the equivalent dose of an index chemical (the chemical selected as a basis for standardization of toxicity of components in a mixture). The equivalent dose is the sum of component doses scaled by their toxic potency relative to the index chemical. For example, for chlorinated dibenzodioxins (CDDs), 2,3,7,8-TCDD is selected as the index chemical; other CDD concentrations are adjusted for their potency relative to 2,3,7,8-TCDD and then treated as if they were 2,3,7,8-TCDD “equivalents.”",
  "subject": "Chemicals, toxics and pesticides",
  "references": [
    "Pesticides Glossary",
    "EPA Framework for Cumulative Risk Assessment Glossary EPA/630/P-02/001F May 2003 EPA Risk Assessment Forum at oaspub.epa.gov/eims"
  ],
  "url": "https://mlchart.com/terminology/environment/dose-additivity/"
}