dose-effect relationship

{
  "id": "MLC-T-ENV-008447",
  "term": "dose-effect relationship",
  "field": "Environment",
  "definition": "1. Relationship between the total amount of an agent administered to, taken up or absorbed by an organism, system or (sub) population and the magnitude of a continuously-graded effect to that organism, system or (sub)population. [IPCS/OECD 2004]\n\n2. Determination of the quantitative relationship between exposure to a particular substance or activity and the incidence or severity of an effect. Dose-response assessment evaluates the conditions under which the effect might occur and considers factors that influence relationships, such as intensity and pattern of exposure and age and lifestyle variables that could affect susceptibility. Such assessments also can involve extrapolation of high-dose responses to low-dose responses and from animal responses to human responses. The development of this relationship may involve the use of mathematical models. [NYS 1998]\n\n3. The relationship between dose (usually an estimate of dose) and the gradation of the effect in a population, that is a biological change measured on a graded scale of severity, although at other times one may only be able to describe a qualitative effect that occurs within some range of exposure levels. [RAIS 2004, SRA 2004]",
  "references": [
    "Thesaurus of Terms Used in Microbial Risk Assessment"
  ],
  "url": "https://mlchart.com/terminology/environment/dose-effect-relationship/"
}