Dose-Response Relationship

Term · Environment · MLC-T-ENV-008452

1. The relationship between a quantified exposure (dose) and the proportion of subjects demonstrating specific biologically significant changes in incidence and/or in degree of change (response).

2. The quantitative relationship between the amount of exposure to a substance and the extent of toxic injury produced.

3. The quantitative relationship between the amount of exposure to a substance and the extent of toxic injury or disease produced.

4. The resulting biological responses in an organ or organism expressed as a function of a series of doses.

5. The relationship between a quantified exposure (dose) and the proportion of subjects demonstrating specific, biological changes (response). See A Review of the Reference Dose and Reference Concentration Processes (EPA, 2002).

6. The relationship between the amount of exposure [dose] to a substance and the resulting changes in body function or health (response).

7. A relationship between (1) the dose, either “administered dose” or absorbed dose and (2) the extent of toxic injury produced by that chemical or agent. Response can be expressed either as the severity of injury or the proportion of exposed subjects affected.

8. The resulting biological responses in an organ or organism expressed as a function of a series of doses. [EPA 1997a]

9. The relationship between a quantified exposure (dose) and the proportion of subjects demonstrating specific biologically significant changes in incidence and/or in degree of change (response). [EPA 2003]

10. The quantitative relationship between the amount of exposure to a substance and the extent of toxic injury or disease produced. [EPA 2005b][Thesaurus of Terms Used in Microbial Risk Assessment]Relationship between the amount of an agent administered to, taken up or absorbed by an organism, system or (sub) population and the change developed in that organism, system or (sub) population in reaction to the agent. [IPCS/OECD 2004]

Table 1. Record
Identifier	MLC-T-ENV-008452
Field	Environment
Subject	Health and safety
References	Integrated Risk Information System (IRIS) Glossary; EPA 2003; Drinking Water Technical & Legal Terms; Terms of Environment; EPA 2005b; Exposure Factors Handbook: Glossary; EPA 1997a; Health Effects Notebook Glossary; CDC Agency for Toxic Substances and Disease Registry Glossary; EPA Framework for Cumulative Risk Assessment Glossary EPA/630/P-02/001F May 2003 EPA Risk Assessment Forum at oaspub.epa.gov/eims; Thesaurus of Terms Used in Microbial Risk Assessment

Record as JSON

{
  "id": "MLC-T-ENV-008452",
  "term": "Dose-Response Relationship",
  "field": "Environment",
  "definition": "1. The relationship between a quantified exposure (dose) and the proportion of subjects demonstrating specific biologically significant changes in incidence and/or in degree of change (response).\n\n2. The quantitative relationship between the amount of exposure to a substance and the extent of toxic injury produced.\n\n3. The quantitative relationship between the amount of exposure to a substance and the extent of toxic injury or disease produced.\n\n4. The resulting biological responses in an organ or organism expressed as a function of a series of doses.\n\n5. The relationship between a quantified exposure (dose) and the proportion of subjects demonstrating specific, biological changes (response). See A Review of the Reference Dose and Reference Concentration Processes (EPA, 2002).\n\n6. The relationship between the amount of exposure [dose] to a substance and the resulting changes in body function or health (response).\n\n7. A relationship between (1) the dose, either “administered dose” or absorbed dose and (2) the extent of toxic injury produced by that chemical or agent. Response can be expressed either as the severity of injury or the proportion of exposed subjects affected.\n\n8. The resulting biological responses in an organ or organism expressed as a function of a series of doses. [EPA 1997a]\n\n9. The relationship between a quantified exposure (dose) and the proportion of subjects demonstrating specific biologically significant changes in incidence and/or in degree of change (response). [EPA 2003]\n\n10. The quantitative relationship between the amount of exposure to a substance and the extent of toxic injury or disease produced. [EPA 2005b][Thesaurus of Terms Used in Microbial Risk Assessment]Relationship between the amount of an agent administered to, taken up or absorbed by an organism, system or (sub) population and the change developed in that organism, system or (sub) population in reaction to the agent. [IPCS/OECD 2004]",
  "subject": "Health and safety",
  "references": [
    "Integrated Risk Information System (IRIS) Glossary; EPA 2003",
    "Drinking Water Technical & Legal Terms",
    "Terms of Environment; EPA 2005b",
    "Exposure Factors Handbook: Glossary; EPA 1997a",
    "Health Effects Notebook Glossary",
    "CDC Agency for Toxic Substances and Disease Registry Glossary",
    "EPA Framework for Cumulative Risk Assessment Glossary EPA/630/P-02/001F May 2003 EPA Risk Assessment Forum at oaspub.epa.gov/eims",
    "Thesaurus of Terms Used in Microbial Risk Assessment"
  ],
  "url": "https://mlchart.com/terminology/environment/dose-response-relationship/"
}

Record 8,452 of 30,736 in Environment terminology (MLC-0121). Request the full dataset.