Polychromatic Erythrocyte

{
  "id": "MLC-T-ENV-021502",
  "term": "Polychromatic Erythrocyte",
  "field": "Environment",
  "definition": "Immature red blood cell that, because it contains RNA, can be differentiated by appropriate staining techniques from a normochromatic erythrocyte (NCE), which lacks RNA. In one to two days, a PCE matures into a NCE.(c) Test method - (1) Principle of the test method. (i) Groups of rodents are exposed by the inhalation route for a minimum of 6 hours/day over a period of not less than 28 days to three or more concentrations of a test substance in air. Groups of animals are sacrificed at the end of the exposure period and femoral bone marrow is extracted. The bone marrow is then smeared onto glass slides, stained, and PCEs are scored for micronuclei. Researchers may need to run a trial at the highest tolerated concentration of the test atmosphere to optimize the sample collection time for micronucleated cells.",
  "abbreviation": "PCE (Blood)",
  "references": [
    "40 CFR 79.64 (CFR 2013)"
  ],
  "url": "https://mlchart.com/terminology/environment/polychromatic-erythrocyte/"
}