Subchronic Dermal Toxicity

{
  "id": "MLC-T-ENV-027074",
  "term": "Subchronic Dermal Toxicity",
  "field": "Environment",
  "definition": "Adverse effects occurring as a result of the repeated daily exposure of experimental animals to a chemical by dermal application for part (approximately 10 percent) of a life span.(2) Dose in a dermal test is the amount of test substance applied to the skin (applied daily in subchronic tests). Dose is expressed as weight of the substance (g, mg) per unit weight of test animal (e.g., mg/kg).(3) No-effect level/No-toxic-effect level/No-adverse-effect level/No-observed-effect level is the maximum dose used in a test which produces no observed adverse effects. A no-observed-effect level is expressed in terms of the weight of a test substance given daily per unit weight of test animal (mg/kg).(4) Cumulative toxicity is the adverse effects of repeated doses occurring as a result of prolonged action on, or increased concentration of the administered test substance or its metabolites in susceptible tissues.",
  "references": [
    "40 CFR 798.2250 (CFR 2013)"
  ],
  "url": "https://mlchart.com/terminology/environment/subchronic-dermal-toxicity/"
}