Synergistic effect

{
  "id": "MLC-T-ENV-027527",
  "term": "Synergistic effect",
  "field": "Environment",
  "definition": "1. A biologic response to multiple substances where one substance worsens the effect of another substance. The combined effect of the substances acting together is greater than the sum of the effects of the substances acting by themselves.\n\n2. Joint effects of two or more agents, such as drugs that increase each other’s effectiveness when taken together.\n\n3. Exposure to multiple stressors that leads to an increased response that exceeds what would be estimated for exposure to each chemical independently.",
  "subject": "Outcomes",
  "references": [
    "ATSDR 2004; see additive effect and antagonistic effect; CDC Agency for Toxic Substances and Disease Registry Glossary; Thesaurus of Terms Used in Microbial Risk Assessment",
    "RAIS 2004, SRA 2004; Thesaurus of Terms Used in Microbial Risk Assessment",
    "EPA ExpoBox Terminology"
  ],
  "url": "https://mlchart.com/terminology/environment/synergistic-effect/"
}