Adenoviral vector encoding VEGF-C LX-1101

{
  "id": "MLC-T-ONC-009680",
  "term": "Adenoviral vector encoding VEGF-C LX-1101",
  "field": "Oncology and biomedicine",
  "definition": "A genetically engineered, replication-deficient adenovirus carrying the gene encoding for the human vascular endothelial growth factor C (VEGFC; VEGF-C; Flt4 ligand), with potential pro-angiogenic activity. Upon perinodal administration of the AdAptVEGF-C adenoviral vector LX-1101, the adenovirus infects cells and promotes expression of VEGF-C. In turn, VEGF-C induces vascular and lymphatic endothelial cell proliferation locally, and may help re-grow the lymphatic system and improve symptoms associated with lymphedema (LE). VEGF-C, a lymphatic growth factor, plays a key role in (lymph)angiogenesis and the functioning of the lymphatic system.",
  "synonyms": [
    "AdAptVEGF-C adenoviral vector LX-1101",
    "VEGFC-expressing gene therapeutic LX-1101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adenoviral-vector-encoding-vegf-c-lx-1101/"
}