adenoviral-transduced hIL-12-expressing autologous dendritic cells INXN-3001 plus activator ligand INXN-1001

{
  "id": "MLC-T-ONC-009681",
  "term": "adenoviral-transduced hIL-12-expressing autologous dendritic cells INXN-3001 plus activator ligand INXN-1001",
  "field": "Oncology and biomedicine",
  "definition": "Autologous dendritic cells tranduced with a replication incompetent adenovirus encoding human pro-inflammatory cytokine interleukin-12 (IL-12) (INXN-3001) in combination with the proprietary orally bioavailable, small molecule activator ligand INXN-1001, with potential immunomodulating and antineoplastic activities. Production of IL-12 is controlled by an inducible DNA element that allows transcription initiation only in the presence of the ligand inducer INXN-1001. Upon intratumoral injection of INXN-3001 and subsequent oral administration of activator ligand, INXN-1001 is able to induce expression of IL-12 in INXN-3001. IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells, inducing the secretion of interferon-gamma and inducing a cytotoxic T lymphocyte response against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation. As INXN-1001 regulates both the timing and the levels of IL-12 expression, IL-12 toxicity can be reduced.",
  "synonyms": [
    "DC-RTS-IL-12"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adenoviral-transduced-hil-12-expressing-autologous-dendritic-cells-inxn-3001/"
}