canarypox-hIL-12 melanoma vaccine

{
  "id": "MLC-T-ONC-012216",
  "term": "canarypox-hIL-12 melanoma vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A vaccine consisting of a replication-defective recombinant canarypox virus (ALVAC) that encodes the gene for human interleukin-12 (hIL-12). Produced mainly by B-cells, IL-12 is an endogenous cytokine that activates natural killer (NK) cells, promotes cytotoxic T lymphocyte (CTL) responses, induces the release of interferon-gamma (IFN-gamma), and may exhibit antitumor and anti-angiogenic effects. Vaccination with canarypox-hIL-12 melanoma vaccine may stimulate the host immune system to mount an immune response against tumor cells, thereby inhibiting tumor growth and/or metastasis.",
  "synonyms": [
    "ALVAC-hIL-12",
    "ALVAC-hIL-12 melanoma vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/canarypox-hil-12-melanoma-vaccine/"
}