AKT-1 antisense oligonucleotide WGI-0301

{
  "id": "MLC-T-ONC-009746",
  "term": "AKT-1 antisense oligonucleotide WGI-0301",
  "field": "Oncology and biomedicine",
  "definition": "A lipid nanoparticle preparation of archexin, a 20-mer antisense (AS) oligodeoxynucleotide (ODN) against the proto-oncogene Akt, with potential antineoplastic activity. Upon administration of AS ODN WGI-0301, archexin binds to Akt-1 mRNA, inhibiting translation of the transcript. Suppression of Akt-1 expression may result in the inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt-mediated signaling. This may inhibit proliferation and induce apoptosis of tumor cells in which Akt-1 is overexpressed. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.",
  "synonyms": [
    "Akt-1 antisense ODN WGI-0301",
    "Akt-1 AS ODN WGI-0301"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/akt-1-antisense-oligonucleotide-wgi-0301/"
}