allogeneic polymer-encapsulated IL-2-secreting retinal pigmented epithelial cells AVB-001

{
  "id": "MLC-T-ONC-009939",
  "term": "allogeneic polymer-encapsulated IL-2-secreting retinal pigmented epithelial cells AVB-001",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of polymer-encapsulated cells, obtained from the human immortalized retinal pigment epithelia (RPE) cell line ARPE-19, that have been genetically engineered to express the human cytokine interleukin-2 (IL-2; IL2), with potential immunomodulatory and antineoplastic activities. Upon intraperitoneal administration, allogeneic polymer-encapsulated IL-2-secreting RPE cells AVB-001 produces IL-2 locally, which binds to the IL-2 receptor (IL-2R) and activates IL-2/IL-2R-mediated signaling. This activates cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells and induces expression of certain cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming growth factor-beta (TGFb). This leads to T-cell-mediated cytotoxic immune responses against tumor cells and inhibition of tumor cell proliferation. The local delivery of AVB-001 reduces systemic toxicities, and the polymer encapsulation allows for longer half-life.",
  "synonyms": [
    "allogeneic polymer-encapsulated IL-2-secreting RPE cells AVB-001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-polymer-encapsulated-il-2-secreting-retinal-pigmented-epithelial-avb/"
}