Anakinra

{
  "id": "MLC-T-ONC-000485",
  "term": "Anakinra",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that is used to treat rheumatoid arthritis, and is being studied in the treatment of cancer. Anakinra blocks the action of interleukin 1 (IL-1). It is a type of interleukin receptor antagonist. Also called Kinaret.",
    "A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis."
  ],
  "abbreviation": "rIL-1ra",
  "synonyms": [
    "Kinaret",
    "interleukin-1 receptor antagonist",
    "IL-1ra"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anakinra/"
}