Recombinant interleukin-1-beta

{
  "id": "MLC-T-ONC-016438",
  "term": "Recombinant interleukin-1-beta",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant therapeutic agent which is chemically identical to or similar to the endogenous protein cytokine interleukin 1 (IL-1)-beta. Produced by monocytes and activated macrophages, endogenous mature IL-1 is generated through proteolytic cleavage by proteases such as IL-1-beta converting enzyme (ICE). This agent promotes angiogenesis, fibroblast proliferation, and neutrophil chemotaxis; it also regulates the functions of lymphocytes and epithelial cells and is involved in the 'acute phase response' to infection.",
  "abbreviation": "IL-1-b",
  "synonyms": [
    "interleukin-1-beta"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/recombinant-interleukin-1-beta/"
}