anti-BCMA antibody SEA-BCMA

{
  "id": "MLC-T-ONC-010157",
  "term": "anti-BCMA antibody SEA-BCMA",
  "field": "Oncology and biomedicine",
  "definition": "A humanized, afucosylated monoclonal antibody created using the proprietary, sugar-engineered antibody (SEA) platform and directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17), with potential immunoadjuvant activity. Upon administration, the anti-BCMA antibody SEA-BCMA targets and binds to BCMA expressed on tumor cells. When administered with antibody-coupled T-cell receptor (ACTR)-expressing T cells, the ACTR-expressing T cells bind, with high affinity, to the anti-BCMA antibody SEA-BCMA. This activates the ACTR T -cells and the T cells induce specific cytotoxic T-lymphocyte (CTL)-mediated cytotoxicity toward BCMA-expressing tumor cells. BCMA, a cell surface protein and member of the tumor necrosis factor (TNF) receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.",
  "synonyms": [
    "anti-BCMA afucosylated monoclonal antibody SEA-BCMA"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-bcma-antibody-sea-bcma/"
}