anti-c-Kit/MMAE antibody-drug conjugate NN3201

{
  "id": "MLC-T-ONC-010478",
  "term": "anti-c-Kit/MMAE antibody-drug conjugate NN3201",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of 2G4, a human monoclonal antibody directed against the stem cell factor receptor c-Kit (SCFR; KIT; CD117), conjugated to the auristatin derivative and microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration of anti-c-Kit/MMAE ADC NN3201, the 2G4 antibody targets and binds to the cell surface antigen c-Kit. Upon binding and internalization, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in c-Kit-expressing tumor cells. c-Kit, a transmembrane protein and receptor tyrosine kinase (RTK) overexpressed in various solid tumors and hematological malignancies, plays a key role in the regulation of cell differentiation and proliferation.",
  "synonyms": [
    "anti-c-Kit ADC NN3201",
    "anti-c-Kit antibody-drug conjugate NN3201",
    "anti-c-Kit/MMAE ADC NN3201",
    "anti-CD117 ADC NN3201",
    "anti-CD117 antibody-drug conjugate NN3201",
    "anti-CD117/MMAE ADC NN3201",
    "anti-CD117/MMAE antibody-drug conjugate NN3201"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-c-kit-mmae-antibody-drug-conjugate-nn3201/"
}