anti-CD123/CD3 BiTE antibody SAR440234

{
  "id": "MLC-T-ONC-010223",
  "term": "anti-CD123/CD3 BiTE antibody SAR440234",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific T-cell engager (BiTE) antibody comprised of a humanized Fc-silenced immunoglobulin G1 (IgG1) backbone and two single-chain variable fragments (scFvs): one directed against the CD3 antigen expressed on T lymphocytes and another directed against the alpha-chain of the interleukin-3 receptor (IL-3RA; CD123), with potential immunostimulating and antineoplastic activities. Upon intravenous infusion, anti-CD123/CD3 BiTE antibody SAR440234 binds to both CD3 expressed on T cells and CD123 expressed on tumor cells. This activates and redirects cytotoxic T lymphocytes (CTLs) to CD123-expressing tumor cells, leading to enhanced CTL-mediated elimination of CD123-expressing tumor cells. CD123 is overexpressed in a variety of hematological malignancies; its expression is low or absent in normal hematopoietic progenitors and stem cells.",
  "synonyms": [
    "bispecific T-cell engager antibody SAR440234",
    "CD123xCD3 bispecific T-cell engager SAR440234"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd123-cd3-bite-antibody-sar440234/"
}