anti-CD123/anti-CD3 bispecific DART molecule MGD024

{
  "id": "MLC-T-ONC-010220",
  "term": "anti-CD123/anti-CD3 bispecific DART molecule MGD024",
  "field": "Oncology and biomedicine",
  "definition": "An Fc-bearing, bispecific antibody-like protein directed against the tumor-associated antigen (TAA) CD123 and the human T-cell surface antigen CD3, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CD123/anti-CD3 bispecific DART molecule MGD024 simultaneously binds to both CD123-expressing cancer cells and CD3-expressing T cells, thereby crosslinking CD123-expressing tumor cells and cytotoxic T lymphocytes (CTLs). This results in the activation and proliferation of T cells and causes CTL-mediated cell lysis of CD123-expressing tumor cells. CD123, the interleukin-3 receptor alpha chain, is overexpressed in a variety of hematological malignancies; its expression is low or absent in normal hematopoietic progenitors and stem cells. The Fc domain prolongs the half-life of the agent, and a reduced affinity of CD3-binding results in less cytokine release.",
  "synonyms": [
    "anti-CD123/CD3 bispecific DART molecule MGD024",
    "CD123 x CD3 bispecific DART molecule MGD024",
    "dual-affinity re-targeting protein MGD024"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd123-anti-cd3-bispecific-dart-molecule-mgd024/"
}