anti-CD19 monoclonal antibody DI-B4

{
  "id": "MLC-T-ONC-010256",
  "term": "anti-CD19 monoclonal antibody DI-B4",
  "field": "Oncology and biomedicine",
  "definition": "A low-fucosylated, humanized, IgG1 isotype, monoclonal antibody directed against the B-cell-specific membrane protein CD19 with potential immunostimulating and antineoplastic activities. Anti-CD19 monoclonal antibody DI-B4 binds to CD19, which may result in a strong antibody-dependent cellular cytotoxicity (ADCC) directed at CD19-expressing B cells but with minimal complement dependent cytotoxicity. DI-B4 contains low levels of fucose, which contributes to its enhanced ADCC activity. CD19 is a B-cell specific membrane antigen that is widely expressed during B-cell development and in all B-cell lineage malignancies.",
  "synonyms": [
    "anti-CD19 MoAb DI-B4"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd19-monoclonal-antibody-di-b4/"
}