anti-CD22/CD3 bispecific antibody JNJ-75348780

{
  "id": "MLC-T-ONC-010317",
  "term": "anti-CD22/CD3 bispecific antibody JNJ-75348780",
  "field": "Oncology and biomedicine",
  "definition": "A human bispecific antibody, with potential antineoplastic activity. Anti-CD22/CD3 bispecific antibody JNJ-75348780 contains two binding sites, one for the tumor-associated antigen (TAA) CD22, and one for the T-cell surface antigen CD3. Upon administration, JNJ-75348780 binds to both CD3 on T cells and CD22-expressing B-lineage tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the CD22-expressing tumor B cells. CD22 is exclusively expressed on B cells and is often overexpressed in B-lymphocytic malignancies. It negatively regulates the B-cell receptor.",
  "synonyms": [
    "CD22 x CD3 bispecific antibody JNJ-75348780"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd22-cd3-bispecific-antibody-jnj-75348780/"
}