anti-CD40 agonist monoclonal antibody CDX-1140

{
  "id": "MLC-T-ONC-010388",
  "term": "anti-CD40 agonist monoclonal antibody CDX-1140",
  "field": "Oncology and biomedicine",
  "definition": "A fully human immunoglobulin G2 (IgG2) agonistic monoclonal antibody targeting the B-cell surface antigen CD40, with potential immunostimulatory and antineoplastic activities. Upon administration, CDX-1140 targets and binds to CD40 on a variety of immune cell types. This induces CD40-dependent signaling pathways, triggers the proliferation and activation of antigen-presenting cells (APCs) and activates T cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as dendritic cells (DCs), macrophages and B cells, and plays a key role in the activation of the immune system.",
  "synonyms": [
    "anti-CD40 agonistic monoclonal antibody CDX-1140",
    "agonist CD40 antibody CDX-1140"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd40-agonist-monoclonal-antibody-cdx-1140/"
}