Fc-engineered anti-CD40 agonist antibody 2141-V11

{
  "id": "MLC-T-ONC-013541",
  "term": "Fc-engineered anti-CD40 agonist antibody 2141-V11",
  "field": "Oncology and biomedicine",
  "definition": "A Fc-engineered agonistic antibody targeting the human B-cell surface antigen CD40, with potential immunostimulatory and antineoplastic activities. Upon intratumoral administration, 2141-V11 targets and binds to CD40 on a variety of immune cell types. This induces CD40-dependent signaling pathways, triggers the proliferation and activation of antigen-presenting cells (APCs) and activates T cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as dendritic cells (DCs), macrophages and B cells, and plays a key role in the activation of the immune system.",
  "synonyms": [
    "Fc-engineered anti-CD40 agonistic antibody 2141-V11",
    "anti-CD40 agonistic antibody 2141-V11",
    "anti-CD40 agonist antibody 2141-V11",
    "Fc-enhanced anti-CD40 antibody 2141-V11"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fc-engineered-anti-cd40-agonist-antibody-2141-v11/"
}