Fc fusion IL-7 mimetic MDK-703

{
  "id": "MLC-T-ONC-013540",
  "term": "Fc fusion IL-7 mimetic MDK-703",
  "field": "Oncology and biomedicine",
  "definition": "A fusion protein composed of MDK-1472, a structurally unrelated engineered mimetic peptide of endogenous human cytokine interleukin-7 (hIL-7), fused to an immunoglobulin G2 (IgG2) Fc-domain, with hematopoietic and immunopotentiating activities. Upon administration, Fc fusion IL-7 mimetic MDK-703 mimics endogenous cytokine IL-7 and binds to the IL-7 receptor (IL7R) on immune cells. The binding of IL-7 to IL7R activates IL7/IL7R-mediated signaling, which leads to the expansion of various subsets of T-lymphocytes, including memory T cells, especially CD8 and CD4 stem cell memory T cells (Tscm), central memory T cells (Tcm) and effector memory T cells (Tem). This may improve immune recovery and activation and may enhance T-cell-mediated anti-tumor immune responses. Fusion to the Fc domain enhances the half-life of the IL-7 mimetic. As MDK-703 is unrelated in sequence to the natural cytokine, it is unlikely to generate anti-drug antibodies (ADAs) that neutralize the endogenous IL-7 cytokine. IL-7 is a cytokine critical for the development, maintenance and survival of T-cell subpopulations.",
  "synonyms": [
    "IL-7 mimetic MDK-703",
    "IL-7R agonist MDK-703",
    "IL-7 PEPTIKINE-Fc-domain fusion protein MDK-703",
    "Fc-peptide-based IL-7 mimetic MDK-703"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fc-fusion-il-7-mimetic-mdk-703/"
}