ribocytokine IL-7 BNT152

{
  "id": "MLC-T-ONC-016535",
  "term": "ribocytokine IL-7 BNT152",
  "field": "Oncology and biomedicine",
  "definition": "A formulation consisting of lipid nanoparticles (LNPs) encapsulating nucleoside-modified messenger RNA (mRNA) encoding the endogenous cytokine interleukin-7 (IL-7), with potential immunostimulating activity. Upon administration, ribocytokine IL-7 BNT152 is taken up by cells and the expressed IL-7 targets and binds to the IL-7 receptor (IL7R). The binding of IL-7 to IL7R activates IL7/IL7R-mediated signaling, which activates B and T lymphocytes, may improve immune recovery and activation, and may enhance anti-tumor immune responses.",
  "synonyms": [
    "human interleukin-7 mRNA-encoded BNT152"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ribocytokine-il-7-bnt152/"
}